DNA

CIMBA

(The Consortium of Investigators of Modifiers of BRCA1/2)
DNA
 

Projects

The main genotyping projects that CIMBA has been involved in to date are as follows. Further details on the results of these projects can be found in the Publications section.

  • Candidate SNP studies for >100 SNPs

  •  
  • GWAS in BRCA1 mutation carriers:
       Stage 1- >500,000 SNPs genotyped in 2727 carriers
       Stage 2- 89 SNPs genotyped in 5,986 carriers

  •  
  • GWAS in BRCA2 mutation carriers:
       Stage 1- >500,000 SNPs genotyped in 1703 carriers
       Stage 2- 85 SNPs genotyped in 2486 carriers

  •  
  • Genotyping on the custom iCOGS array, as part of the Collaborative Oncological Gene-environment Study (COGS) Consortium:
       BRCA1- >200,000 SNPs genotyped in 15,170 carriers
       BRCA2- >200,000 SNPs genotyped in 8,211 carriers

  •    Approximately 51,000 of these SNPs were selected on the basis of the BRCA1/2 GWAS.

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