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CIMBA

(The Consortium of Investigators of Modifiers of BRCA1/2)
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Authorship Guidelines(pdf)


Publications:

Hollestelle et al. (2015) No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer. Gynecologic Oncology S0090-8258(15)00863-X. doi: 10.1016/j.ygyno.2015.04.034

Blein et al. (2015) An original phylogenetic approach identified mitochondrial haplogroup T1a1 as inversely associated with breast cancer risk in BRCA mutation carriers. Breast Cancer Research 17(1):61

Blanco et al. (2015) Assessing associations between the HMMR-AURKA-TPX2-TUBG1 functional module and breast cancer risk in BRCA1/2 mutation carriers. PLOS One 10(4):e0120020

Rebbeck et al. (2015) Association of Type and Location of BRCA1 and BRCA2 Mutations with Risk of Breast and Ovarian Cancer. JAMA 313:1347-1361

Candido Dos Reis et al. (2015) Germline mutation in BRCA1 or BRCA2 and ten year survival in epithelial ovarian cancer. Clinical Cancer Research 21(3)652-57

Kuchenbaecker et al. (2015) Identification of six new susceptibility loci for invasive epithelial ovarian cancer. Nature Genetics 47(2)164-71

Peterlongo et al. (2015) Candidate genetic modifiers for breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers. Cancer Epidemiology Biomarkers and Prevention 24(1)308-316

Spurdle et al. (2014) Refined histopathological predictors of BRCA1 and BRCA2 mutation status: a large-scale analysis of breast cancer characteristics from the BCAC, CIMBA, and ENIGMA consortia Breast Cancer Research 16(6)3419

Kuchenbaecker et al. (2014) Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers. Breast Cancer Research 16(6)3416

Osorio et al. (2014) DNA glycosylases involved in base excision repair may be associated with cancer risk in BRCA1 and BRCA2 mutation carriers. PLOS Genetics10(4):e1004256

Gaudet et al. (2013) Identification of a BRCA2-specific modifier locus at 6p24 related to breast cancer risk. PLoS Genetics 9(3)e1003173

Couch et al. (2013) Genome wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk. PLoS Genetics 9(3):e1003212

Bojesen et al. (2013) Multiple independent TERT variants associated with telomere length and risks of breast and ovarian cancer. Nature Genetics 45(4):371-84

Ding et al. (2012) A nonsynonymous polymorphism in IRS1 modifies risk of developing breast and ovarian cancers in BRCA1 and ovarian cancer in BRCA2 mutation carriers. Cancer Epidemiol Biomarkers Prev 21(8):1362-1370

Kirchhoff et al. (2012) Breast cancer risk and 6q22.33: combined results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2. PLoS One 7(6):e35706 (Epub)

Jakubowska et al. (2012) Association of PHB 1630 C>T and MTHFR 677 C>T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study. British Journal of Cancer 106(12):2016-2024

Maia et al. (2012) Effects of BRCA2 cis-regulation in normal breast and cancer risk amongst BRCA2 mutation carriers. Breast Cancer Res 14(2):R63 (Epub ahead of print)

Couch et al. (2012) Common variants at the 19p13.1 and ZNF365 loci are associated with ER subtypes of breast cancer and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers. Cancer Epidemiology Biomarkers Prev 21(4):645-657

Laitman et al. (2012) The KL-VS sequence variant of Klotho and cancer risk in BRCA1 and BRCA2 mutation carriers. Breast Cancer Res Treat 132(3):1119-1126

Antoniou et al. (2012) Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers. Breast Cancer Res 14(1):R33 (Epub ahead of print)

Ramus, Antoniou et al. (2012) Ovarian cancer susceptibility alleles and risk of ovarian cancer in BRCA1 and BRCA2 mutation carriers. Human Mutation 33(4):690-702

Bolton KL, Chenevix-Trench G, Goh C, Sadetzki S, Ramus SJ, Karlan BY, et al. (2012) Association between BRCA1 and BRCA2 mutations and survival in women with invasive epithelial ovarian cancer JAMA 307(4):382-90

Mavaddat, et al. (2012) Pathology of breast and ovarian cancers among BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) Cancer Epidemiology Biomarkers Prev Jan;21(1):134-47

Cox, et al. (2011) Common variants of the BRCA1 wild-type allele modify the risk of breast cancer in BRCA1 mutation carriers. Hum Mol Genet 20(23):4732-4747

Mulligan, et al. (2011) Common breast cancer susceptibility alleles are associated with tumor subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2. Breast Cancer Res 13(6):R110 [Epub ahead of print]

Maxwell, et al. (2011) Interplay between BRCA1 and RHAMM Regulates Epithelial Apicobasal Polarization and May Influence Risk of Breast Cancer. PLoS Biol 9(11):e1001199 Epub

Spurdle, et al. (2011) Common genetic variation at BARD1 is not associated with breast cancer risk in BRCA1 or BRCA2 mutation carriers. Cancer Epidemiology Biomarkers and Prevention 20: 1032-1038

Martrat, et al. (2011) Exploring the link between MORF4L1 and risk of breast cancer. Breast Cancer Research 13(2):R40 [Epub ahead of print]

Osorio, et al (2011) Evaluation of the XRCC1 gene as a phenotypic modifier in BRCA1/2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA) British Journal of Cancer 104(8):1356–1361

Im, et al. (2011) Haplotype Structure in Ashkenazi Jewish BRCA1 and BRCA2 Mutation Carriers. Human Genetics 130(5):685-99

Antoniou, et al. (2011) Common alleles at 6q25.1 and 1p11.2 are associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers. Human Molecular Genetics 20(16):3304-21

Ramus, et al. (2011) Genetic Variation at 9p22.2 modifies ovarian cancer risks in BRCA1 and BRCA2 carriers. Journal of the National Cancer Institute 103(2):105-116

Antoniou, et al. (2010) A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor–negative breast cancer in the general population. Nature Genetics 42(10):885-92

Engel, et al. (2010) Association of the Variants CASP8 D302H and CASP10 V410I with Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers. Cancer Epidemiology Biomarkers and Prevention 19:2859-2868

Antoniou, et al. (2010) Common breast cancer susceptibility alleles and the risk of breast cancer for BRCA1 and BRCA2 mutation carriers:implications for risk prediction. Cancer Research 70(23):9742-54

Kaufman, et al. (2011) The CYP17A1 -34T>C polymorphism and breast cancer risk in BRCA1 and BRCA2 mutation carriers. Breast Cancer Research and Treatment 126(2)521-7 (2011)

Gaudet, et al. (2010) Common genetic variants and modification of penetrance of BRCA2-associated breast cancer. PLoS Genet 6(10):e1001183 Published online October 28

Walker, et al. (2010) Evidence for SMAD3 as a modifier of breast cancer risk in BRCA2 mutation carriers. Breast Cancer Research 12(6):R102[Epub]

Wang, et al (2010) Common variants associated with breast cancer in genome-wide association studies are modifiers of breast cancer risk in BRCA1 and BRCA2 mutation carriers. Hum Mol Genet 19(14):2886-97

Jakubowska, et al. (2010) The Leu33Pro polymorphism in the ITGB3 gene does not modify BRCA1/2-associated breast or ovarian cancer risks: results from a multicenter study among 15,542 BRCA1 and BRCA2 mutation carriers. Breast Cancer Research and Treatment 121(3):639-49

Spurdle, et al. (2010) Pooled analysis indicates that the GSTT1 deletion, GSTM1 deletion, and GSTP1 Ile105Val polymorphisms do not modify breast cancer risk in BRCA1 and BRCA2 mutation carriers. Breast Cancer Res Treat 122(1):281-285

Osorio et al. (2009) Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2. (CIMBA) British Journal of Cancer 101(12):2048-54

Antoniou, et al. (2009) Common variants in LSP1, 2q35 and 8q24 and breast cancer risk for BRCA1 and BRCA2 mutation carriers. Human Molecular Genetics 18(22):4442-56

Sinilnikova, et al. (2009) The TP53 Arg72Pro and MDM2 309G4T polymorphisms are not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers. British Journal of Cancer 101(8):1456–1460

Rebbeck, et al. (2009) No association of TGFB1 L10P genotypes and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a multi-center cohort study. Breast Cancer Res Treat 115(1):185-92

Johnatty, et al. (2009) No evidence that GATA3 rs570613 SNP modifies breast cancer risk. Breast Cancer Research and Treatment 117(2):371-9

Osorio, et al. (2008) An evaluation of the polymorphisms Ins16bp and Arg72Pro in p53 as breast cancer risk modifiers in BRCA1 and BRCA2 mutation carriers. British Journal of Cancer 99(6):974-7

Antoniou, et al. (2008) Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers. Am J Hum Genet 82(4):937-48

Couch, et al. (2007) AURKA F31I Polymorphism and Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers: A Consortium of Investigators of Modifiers of BRCA1/2 Study. Cancer Epidemiol Biomarkers Prev 16(7):1416-21

Antoniou, et al. (2007) RAD51 135G-->C Modifies Breast Cancer Risk among BRCA2 Mutation Carriers: Results from a Combined Analysis of 19 Studies. Am J Hum Genet 81(6):1186-200

Chenevix-Trench, et al. (2007) An international initiative to identify genetic modifiers of BRCA1 and BRCA2: the Consortium of Investigators of Modifiers of BRCA1 and BRCA2 (CIMBA). Breast Cancer Research 9(2):104


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